Population distribution of the functional caspase-12 allele
نویسندگان
چکیده
منابع مشابه
Distribution of the mutated delta 32 allele of CCR5 co-receptor gene in Iranian population
Background :The CCR5 is a chemokine receptor that serves as a co-receptor for HIV-1 attachment and entry to T lymphocytes. A 32bp deletion (∆32) in this gene is believed to be associated with resistance to infection and delay disease progression. The aim of this study was to determine the ∆32 allele frequency in healthy individuals and HIV-infected individuals with AIDS. Methods : In this e...
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in fact, this study focused on the following questions: 1. is there any difference between the effect of functional/notional approach and the structural approaches to language teaching on the proficiency test of efl learners? 2. can a rather innovative language test referred to as "functional test" ge devised so so to measure the proficiency test of efl learners, and thus be as much reliable an...
15 صفحه اولdistribution of the mutated delta 32 allele of ccr5 co-receptor gene in iranian population
background :the ccr5 is a chemokine receptor that serves as a co-receptor for hiv-1 attachment and entry to t lymphocytes. a 32bp deletion (∆32) in this gene is believed to be associated with resistance to infection and delay disease progression. the aim of this study was to determine the ∆32 allele frequency in healthy individuals and hiv-infected individuals with aids. methods : in this exp...
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Community-acquired pneumonia (CAP) is a common cause of sepsis. Active full-length caspase-12 (CASP12L), confined to the people of African descent, has been associated with increased susceptibility to and mortality from severe sepsis. The objective of this study was to determine whether CASP12L was a marker for susceptibility and/or severity of CAP. We examined three CAP cohorts and two control...
متن کاملThe Loss of Functional Caspase-12 in Europe Is a Pre-Neolithic Event
BACKGROUND Caspase-12 (CASP12) modulates the susceptibility to sepsis. In humans, the "C" allele at CASP12 rs497116 has been associated with an increased risk of sepsis. Instead, the derived "T" allele encodes for an inactive caspase-12. Interestingly, Eurasians are practically fixed for the inactive variant, whereas in Sub-Saharan Africa the active variant is still common (~24%). This marked s...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2006
ISSN: 1059-7794,1098-1004
DOI: 10.1002/humu.9448